Трансформирующий ростовой фактор, бета-1

Трансформирующий ростовой фактор, бета-1
Трансформирующий ростовой фактор, бета-1
	; PDB rendering based on 1kla.
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Идентификаторы
Символ	TGFB1 ; CED; DPD1; LAP; TGFB; TGFbeta
Внешние ID	OMIM: 190180 MGI: 98725 HomoloGene: 540 ChEMBL: 1795178 GeneCards: TGFB1 Gene
Генная онтология
Генная онтология
Функция	• glycoprotein binding; • antigen binding; • type II transforming growth factor beta receptor binding; • cytokine activity; • protein binding; • growth factor activity; • enzyme binding; • type I transforming growth factor beta receptor binding; • type III transforming growth factor beta receptor binding; • protein homodimerization activity; • protein heterodimerization activity; • protein N-terminus binding;
Компонент клетки	• extracellular region; • proteinaceous extracellular matrix; • extracellular space; • nucleus; • cytoplasm; • Golgi lumen; • plasma membrane; • microvillus; • cell surface; • axon; • platelet alpha granule lumen; • neuronal cell body; • blood microparticle;
Биологический процесс	• protein import into nucleus, translocation; • negative regulation of transcription from RNA polymerase II promoter; • MAPK cascade; • ureteric bud development; • response to hypoxia; • epithelial to mesenchymal transition; • negative regulation of protein phosphorylation; • positive regulation of protein phosphorylation; • regulation of sodium ion transport; • chondrocyte differentiation; • hematopoietic progenitor cell differentiation; • connective tissue replacement involved in inflammatory response wound healing; • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; • tolerance induction to self antigen; • platelet degranulation; • protein phosphorylation; • protein export from nucleus; • ATP biosynthetic process; • phosphate-containing compound metabolic process; • cellular calcium ion homeostasis; • inflammatory response; • cell cycle arrest; • mitotic cell cycle checkpoint; • epidermal growth factor receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • common-partner SMAD protein phosphorylation; • SMAD protein complex assembly; • SMAD protein import into nucleus; • negative regulation of neuroblast proliferation; • salivary gland morphogenesis; • endoderm development; • female pregnancy; • aging; • blood coagulation; • negative regulation of DNA replication; • positive regulation of cell proliferation; • negative regulation of cell proliferation; • germ cell migration; • response to radiation; • response to wounding; • response to glucose; • defense response to fungus, incompatible interaction; • positive regulation of vascular endothelial growth factor production; • positive regulation of gene expression; • negative regulation of gene expression; • negative regulation of extracellular matrix disassembly; • positive regulation of epithelial to mesenchymal transition; • macrophage derived foam cell differentiation; • positive regulation of fibroblast migration; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of macrophage cytokine production; • oligodendrocyte development; • cell growth; • regulation of striated muscle tissue development; • regulation of transforming growth factor beta receptor signaling pathway; • modulation by virus of host morphology or physiology; • evasion or tolerance of host defenses by virus; • viral life cycle; • negative regulation of cell-cell adhesion; • platelet activation; • extracellular matrix organization; • hyaluronan catabolic process; • negative regulation of ossification; • negative regulation of cell growth; • regulation of cell migration; • positive regulation of cell migration; • positive regulation of bone mineralization; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of histone deacetylation; • organ regeneration; • positive regulation of protein complex assembly; • positive regulation of exit from mitosis; • lipopolysaccharide-mediated signaling pathway; • positive regulation of cellular protein metabolic process; • response to estradiol; • response to progesterone; • regulation of interleukin-23 production; • negative regulation of interleukin-17 production; • positive regulation of interleukin-17 production; • receptor catabolic process; • positive regulation of superoxide anion generation; • mononuclear cell proliferation; • positive regulation of collagen biosynthetic process; • positive regulation of peptidyl-serine phosphorylation; • response to vitamin D; • response to laminar fluid shear stress; • positive regulation of histone acetylation; • positive regulation of protein dephosphorylation; • negative regulation of T cell proliferation; • regulation of protein import into nucleus; • positive regulation of protein import into nucleus; • positive regulation of odontogenesis; • response to drug; • myelination; • regulation of apoptotic process; • myeloid dendritic cell differentiation; • T cell homeostasis; • positive regulation of apoptotic process; • positive regulation of MAP kinase activity; • protein kinase B signaling; • positive regulation of blood vessel endothelial cell migration; • negative regulation of blood vessel endothelial cell migration; • positive regulation of phosphatidylinositol 3-kinase activity; • ossification involved in bone remodeling; • regulatory T cell differentiation; • cell-cell junction organization; • negative regulation of cell differentiation; • negative regulation of fat cell differentiation; • negative regulation of myoblast differentiation; • negative regulation of cell cycle; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • negative regulation of mitotic cell cycle; • positive regulation of transcription from RNA polymerase II promoter; • active induction of host immune response by virus; • positive regulation of isotype switching to IgA isotypes; • cell development; • lymph node development; • digestive tract development; • negative regulation of skeletal muscle tissue development; • inner ear development; • positive regulation of epithelial cell proliferation; • negative regulation of epithelial cell proliferation; • positive regulation of protein secretion; • negative regulation of phagocytosis; • positive regulation of chemotaxis; • positive regulation of NF-kappaB transcription factor activity; • regulation of binding; • regulation of DNA binding; • positive regulation of smooth muscle cell differentiation; • negative regulation of release of sequestered calcium ion into cytosol; • positive regulation of protein kinase B signaling; • regulation of blood vessel remodeling; • face morphogenesis; • frontal suture morphogenesis; • pathway-restricted SMAD protein phosphorylation; • positive regulation of SMAD protein import into nucleus; • SMAD protein signal transduction; • mammary gland branching involved in thelarche; • branch elongation involved in mammary gland duct branching; • regulation of branching involved in mammary gland duct morphogenesis; • negative regulation of gene silencing by miRNA; • regulation of cartilage development; • lens fiber cell differentiation; • response to cholesterol; • positive regulation of cell cycle arrest; • cellular response to organic cyclic compound; • cellular response to dexamethasone stimulus; • cellular response to transforming growth factor beta stimulus; • extracellular matrix assembly; • positive regulation of branching involved in ureteric bud morphogenesis; • extrinsic apoptotic signaling pathway; • negative regulation of hyaluronan biosynthetic process; • positive regulation of extracellular matrix assembly; • positive regulation of NAD+ ADP-ribosyltransferase activity; • regulation of actin cytoskeleton reorganization; • positive regulation of transcription regulatory region DNA binding;
	Источники: Amigo / QuickGO
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Ортологи

Трансформирующий ростовой фактор, бета-1 (ТРФбета-1) — белок человека, являющийся первым описанным членом семейства ТРФ-бета, которое, в свою очередь, является частью обширного суперсемейства ТРФ-бета. Ген TGFB1, кодирующий данный белок, находится у человека на 19-й хромосоме.

Клиническое значение

Мутации TGFB1 вызывают болезнь Камурати-Энгельманна I типа (OMIM 131300).

См. также

Трансформирующий ростовой фактор, бета-2
Трансформирующий ростовой фактор, бета-3
TGFBI — «TGF-β-индуцируемый белок»

Ссылки

TGF-бета1 (трансформирующий фактор роста бета1) — medbiol.ru
TGFb (трансформирующий ростовой фактор-бета, ТРФ-бета) — medbiol.ru